Very high risk of cancer in familial Peutz-Jeghers syndrome.

By F. Giardiello, J. Brensinger, A. C. Tersmette, S. Goodman, G. M. Petersen, S. Booker, M. Cruz-Correa, J. Offerhaus. Gastroenterology, 2000

1,408 citations recorded by the source corpus.

Subfields: Epidemiology, Obstetrics and Gynecology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/1010b04c93d967be24b10745770fc01994043636

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. D. Hardie
2. S. Hawley
3. Michael Pollak
4. R. Peek
5. Nahum Sonenberg
6. Alec C. Kimmelman
7. R. DePinho

In Pathology and Forensic Medicine

1. D. Hardie
2. Japanese Gastric Cancer Association

Citations in the corpus

• Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED) (2011, positive): “…1% – 3% are clearly vertically inherited familial syndromes, such as hereditary diffuse gastric gancer [162,163], Lynch syndrome [164, 165], Peutz – Jeghers syndrome [166,167], and familial adenoma-tous polyposis [168], in which the risk of gastric cancer and carcinogenesis is well established.”
• Epidemiology of pancreatic cancer: an overview (2009, background): “A study has shown that germline mutations of the STK11 gene on chromosome 19p cause this disorder”
• Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. (2006, background): “characterized not only by multiple gastrointestinal polyps but also by a significantly increased lifetime risk (approaching 80%) of various epithelial cancers, including breast cancer (6).”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “PJS patients are primarily afflicted with benign intestinal polyposis at a young age (Cooper 1998), although advancing age carries increased risk of gastrointestinal malignancies including a >40-fold increase in PDAC (Giardiello et al. 2000).”
• Pancreatic cancer biology and genetics (2002, background): “, although advancing age carries an increased risk of developing gastrointestinal malignancies, including a more than 40-fold increase in pancreatic adenocarcinom”
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade (2003, background): “People with PJS develop benign polyps in the gastrointestinal tract but also have a 15-fold increased risk of developing malignant tumors in other tissues [9,10].”
• Peutz–Jeghers syndrome: a systematic review and recommendations for management (2010, neutral): “Although very rare, upper GI cancer has been reported during the first and second decades of life.(53) The other indication for surveillance is the detection of large polyps allowing early therapy and the prevention of polyp related symptoms.”
• AMP‐activated protein kinase – development of the energy sensor concept (2006, background): “PJS subjects develop numerous benign tumours in the gastrointestinal tract, but also have a 20-fold increased risk of developing malignant tumours at other sites (Giardiello et al. 2000).”
• Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. (2021, background): “elevated risk for developing pancreatic cancer, reported to be increased by as much as 132-fold.(73,74) Furthermore, STK11 undergoes somatic mutation in approximately 5% of pancreatic cancers.”