Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

By C. López-García, Allon M. Klein, Benjamin D. Simons, D. Winton. Science, 2010

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The intestinal crypt, a prototype stem cell compartment. (2013, background): “From short- and long-term clonal tracing data of individual Lgr5hi cells, it has been deduced that stem cells do not divide asymmetrically (Figure 4C) (Lopez-Garcia et al., 2010; Snippert et al., 2010).”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “Lineage tracing experiments have shown that ISCs, rather than dividing asymmetrically to generate daughter cells of different fates, divide symmetrically and adopt stem or transit-amplifying fates in a stochastic manner [162,163].”
Type 2 alveolar cells are stem cells in adult lung. (2013, positive): “It will also be important to carry out statistical analysis of changes in clone size over time under different conditions, as done recently in other organ systems (17, 44).”
Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay For Stem Cells (2011, methodology): “An increasingly widely used assay in the neural stem cell field is the neuronal colony-forming cell assay (Louis et al., 2008), in which cells are cultured in a collagen-containing semi-solid matrix with EGF and/or bFGF.”
Chaste: An Open Source C++ Library for Computational Physiology and Biology (2013, methodology): “This prediction has since been confrrmed experimentally [38,39].”