CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

By Seiji Tanaka, Toshiko Umemori, K. Hirai, Sachiko Muramatsu, Y. Kamimura, Hiroyuki Araki. 2007

519 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. Kumagai
2. W. G. Dunphy
3. Hiroyuki Araki
4. Johannes C. Walter
5. J. Diffley

In Molecular Biology

1. A. Kumagai
2. W. G. Dunphy
3. S. Bell
4. Hiroyuki Araki
5. Masato T. Kanemaki
6. C. Ramsoomair
7. Lorraine De Jesús-Kim
8. L. Friedman

Citations in the corpus

• In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, background): “Disordered DONSON residues (1-6, 26-154, 330-369) were deleted, leaving only the globular domain and GINS-binding peptide (residues 7-25).”
• DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7 (2020, background): “Current models propose that a network of interactions between Sld3, Dpb11, Sld2, and GINS are required to form the CMG (Tanaka et al., 2007; Zegerman and Diffley, 2007; Muramatsu et al., 2010).”
• CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. (2010, background): “CDK-catalyzed phosphorylation of Sld2 and Sld3, and their subsequent association with Dpb11, is essential for the initiation of chromosomal DNA replication in budding yeast (Tanaka et al. 2007; Zegerman and Diffley 2007).”
• DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans (2023, unknown): “Finally, the metazoan orthologue of yeast Dpb11, known variously as TOPBP1 or MUS101, contains more BRCT domains than Dpb11 (31), and a study of Xenopus TOPBP1 indicated that BRCTs 4-8 are dispensable for replication initiation (32), despite containing the presumed binding site for RECQL4.”
• Concerted Loading of Mcm2-7 Double Hexamers Around DNA during DNA Replication Origin Licensing (2009, background): “CDKs work by phosphorylating Sld2 and Sld3, which generates binding sites for tandem pairs of BRCT repeats in Dpb11 (Tanaka et al., 2007; Zegerman and Diffley, 2007), while DDK phosphorylates Mcm2–7 directly (Sheu and Stillman, 2006).”
• MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication (2017, background): “These phosphorylations promote the docking of Sld2 and Sld3 with Dpb11, the yeast homologue of vertebrate TopBP1.”
• A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. (2010, background): “In particular, we wondered whether Ticrr might be the vertebrate ortholog of the budding yeast protein Sld3, which interacts with Dpb11 and is required for DNA replication initiation (Kamimura et al. 2001; Tanaka et al. 2007; Zegerman and Diffley 2007).”
• Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication (2010, background): “Hence, Dpb11 appears to be acting, at least in part, as a scaffolding protein that helps to position other replication proteins for initiation.”