Likelihood based approaches to handling data below the quantification limit using NONMEM VI

By Jae Eun Ahn, M. O. Karlsson, A. Dunne, T. Ludden. Journal of Pharmacokinetics and Pharmacodynamics, 2008

346 citations recorded by the source corpus.

Subfields: Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/0f19264fa553fbe713911de30913caf19241431c

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In Statistics and Probability

1. M. Bergstrand
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Citations in the corpus

• Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development—Part 2: Introduction to Pharmacokinetic Modeling Methods (2013, neutral): “22,23 Therefore, the CL of the ith subject (CLi) would be written as: CLi i = ( ) θ η 1 1 ⋅ exp (5)”
• Handling Data Below the Limit of Quantification in Mixed Effect Models (2009, methodology): “performance of the M3 method compared to the original implementation (3,7).”