Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes.

By O. Toussaint, E. Medrano, T. Zglinicki. Experimental Gerontology, 2000

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Oxidative Stress in Aging Human Skin (2015, background): “Senescence is initiated after such dramatic incidences as severe DNA damage, critical telomere shortening, oxidative stress and hyperactive oncogenic RAS [339–342].”
Inflammation and aging: signaling pathways and intervention therapies (2023, background): “In the laboratory aging of human diploid fibroblasts (HDFs), as the cells undergo a certain number of population doublings, telomeres become shorter, leading to cell cycle arrest, reduced cell saturation density, and increased cell surface and volume.(280) Hydrogen peroxide is commonly used to induc”
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence (2017, background): “Premature stress-induced senescence is more common in non-proliferating cells and is caused primarily by oxidative stress and DNA damage [16].”