Hydrogen Bonds in Proteins: Role and Strength

By Roderick E. Hubbard, Muhammad K. Haider. 2010

448 citations recorded by the source corpus.

Subfields: Molecular Biology, Physical and Theoretical Chemistry, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/0f087999e289a15716c8a07df316d96e5e2e38ab

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David Baker
2. Jeffrey J. Gray
3. Tanja Kortemme
4. Rhiju Das
5. Frank DiMaio
6. Hahnbeom Park
7. Brian Kuhlman
8. Jens Meiler

In Physical and Theoretical Chemistry

1. Sergei Grudinin
2. Guillaume Pagès
3. Mikhail Karasikov

In Spectroscopy

1. David Baker
2. Hahnbeom Park
3. Richard Bonneau
4. Brian Kuhlman
5. Frank DiMaio
6. Tanja Kortemme
7. Jeffrey J. Gray
8. Roland L. Dunbrack

Citations in the corpus

• Smooth orientation-dependent scoring function for coarse-grained protein quality assessment (2018, methodology): “To study this, we conducted a computational experiment where we trained SBROD on different subsets of the CASP[5-10] datasets using both CASP server submissions and NMA-based decoy protein models (see section B.”
• Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2 (2022, background): “We 279 classified variants causing substitutions of residues responsible for forming direct hydrogen 280 bonds with the DNA to amino acids that are incapable of forming hydrogen bonds (Ala, Cys, 281 Gly, Ile, Leu, Met, Phe, Pro, Val) as resulting in compromised DNA binding while other 282 substituti”
• The Rosetta all-atom energy function for macromolecular modeling and design (2017, background): “Hydrogen bonds are partially covalent interactions that form when a nucleophilic heavy atom donates electron density to a polar hydrogen.”