Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis

By T. Mimura, F. Rizzello, U. Helwig, G. Poggioli, S. Schreiber, Ic Talbot, Rj Nicholls, P. Gionchetti, M. Campieri, M. Kamm. Gut, 2003

949 citations recorded by the source corpus.

Subfields: Food Science, Gastroenterology, Genetics

View Paper: https://www.semanticscholar.org/paper/0ef8a1d5c433d6a8b1974899a139c989e51b2239

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. T. Kanai
2. K. Matsuoka
3. R. Sartor

In Gastroenterology

1. T. Kanai
2. K. Matsuoka

In Genetics

1. T. Kanai
2. K. Matsuoka
3. R. Sartor
4. J. Turner

Citations in the corpus

• The gut microbiota and inflammatory bowel disease (2014, positive): “#3 in the prevention of recurrence in patients with chronic relapsing pouchitis [60, 61].”
• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Nonetheless, intervention with a multispecies consortium of bacteria was shown to be effective in the induction and maintenance of remission in patients with UC (Mimura et al., 2004; Sood et al., 2009), but not in those with CD (Fedorak et al.”
• VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis (2005, background): “VSL#3 has been convincingly demonstrated, in randomized controlled clinical trials, to prevent the recurrence pouchitis following antibiotic-induced remission (29, 30) and postoperatively (31).”
• Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body (2021, positive): “Patients on VSL#3 had no relapse as compared to 6% in patients treated with placebo (150, 151).”
• Microencapsulation of probiotics for gastrointestinal delivery. (2012, result): “Another study by Mimura et al [10] indicated that a probiotic mix of bifidobacteria, lactobacilli, streptococci and Escherichia coli maintained antibiotic induced remission in patients with pouchitis, an ileal pouch inflammation associated with the treatment of ulcerative colitis.”
• Guidelines for the management of inflammatory bowel disease in adults (2011, positive): “Treatment of pouchitis A number of trials exist to support the use of antibiotics and probiotics in the treatment and prevention of pouchitis.(63) 64 113 119 314e317 Other agents have been used in resistant pouchitis include budesonide,(318) 319 ciclosporin,(320) short-chain fatty acids,(321) and in”