Metastatic Colonization

By J. Massagué, A. Obenauf. Nature, 2016

1,745 citations recorded by the source corpus.

Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as latent tumour-initiating seeds and eventually breaking out to replace the host tissue. They make metastasis a highly inefficient process. However, once metastases have been established, current treatments frequently fail to provide durable responses. An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.

Subfields: Biotechnology, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/0ea4b140bbc8fabc484ee21c11f398aba1f9b9b3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Y. Fouad
2. C. Aanei
3. Raghu Kalluri

In Oncology

1. Y. Fouad
2. C. Aanei
3. Raghu Kalluri
4. Ralph J. Deberardinis
5. R. Weinberg
6. D. Hanahan

In Psychiatry and Mental health

1. Y. Fouad
2. C. Aanei

Citations in the corpus

• Revisiting the hallmarks of cancer. (2017, positive): “For cancer cells to occur at distant sites they must 1) invade through the extracellular matrix (ECM), including the basement membrane, and stromal cells, 2) intravasate into tumor vasculature, 3) survive transport in circulation, 4) extravasate at parenchyma of distant organs, and 5) survive and ma”
• Metabolic reprogramming and cancer progression (2020, background): “Colonization includes cell survival in dormant micrometastatic lesions and eventually reactivation of growth, leading to clinically apparent macrometastases (90, 91).”
• Systems Biology of Cancer Metastasis (2019, background): “…initially understood, with evidence suggesting that single or clusters of cells could disseminate from the primary tumor mass(Aceto et al., 2014; Massague and Obenauf, 2016; Ye et al., 2015; Yu et al., 2013), and that these programs are both cell intrinsic(Alexander et al., 2008), and triggered…”