BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing

By K. Tsuji, Amitabha Bandyopadhyay, B. Harfe, K. Cox, S. Kakar, L. Gerstenfeld, T. Einhorn, C. Tabin, V. Rosen. Nature Genetics, 2006

851 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0e9ba16fddb544fc1bf70ccb4f408c6cebdf3ba9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. T. Einhorn
2. Fanxin Long
3. Wenhao Wang
4. K. Yeung

In Molecular Biology

1. Fanxin Long
2. D. Ornitz
3. T. Einhorn

Citations in the corpus

• Development of the endochondral skeleton. (2013, background): “Interestingly, mice lacking only BMP2 in the limb mesenchyme form bone during embryogenesis but display a clear defect in postnatal bone mineral density, resulting in frequent fractures that fail to heal (Tsuji et al. 2006).”
• Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis (2008, background): “It is rich in chondrocyte-like cells, fibroblasts, and oval cells, which are morphologically intermediate between fibroblasts and chondrocytes (Vauhkonen et al., 1990; Aronson, 1994b; Sato et al., 1998).”
• Building strong bones: molecular regulation of the osteoblast lineage (2011, background): “Furthermore, mice lacking only BMP2 in the limb mesenchyme formed bone during embryogenesis but exhibited a clear defect in bone mineral density shortly after birth, resulting in frequent fractures that failed to hea”
• Bone Morphogenetic Protein (BMP) signaling in development and human diseases (2014, neutral): “BMP2, while dispensable for bone formation, is required for the initiation of fracture healing.(8) In limb-specific BMP2 knockouts, the bones lacking BMP2 have spontaneous fractures and an inability to initiate the early stages of fracture healing.”
• Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness (2018, background): “and BMP-2 has been shown to activate Runx2 in a number of cell types, as well a play a crucial role in bone repair.(32)”
• Growth hormone, insulin-like growth factors, and the skeleton. (2008, neutral): “osteoblasts and for bone formation (88-90).”