Bone Morphogenetic Protein (BMP) signaling in development and human diseases

By Richard N. Wang, Jordan D. Green, Zhongliang Wang, Youlin Deng, Min Qiao, Michael Peabody, Qian Zhang, Jixing Ye, Zhengjian Yan, S. Denduluri and 10 more. Genes and Diseases, 2014

965 citations recorded by the source corpus.

Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially discovered for their ability to induce bone formation, BMPs are now known to play crucial roles in all organ systems. BMPs are important in embryogenesis and development, and also in maintenance of adult tissue homeostasis. Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects, highlighting the essential functions of BMPs. In this review, we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development. A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling.

Subfields: Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/e2b1e280d026b5790a26b8271a4afbb424c40175

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In Molecular Biology

1. D. Tang
2. R. Kang
3. Guido Kroemer
4. Xin Chen
5. Maksim V. Plikus
6. V. Horsley
7. L. Galluzzi
8. D. Klionsky

Citations in the corpus

• Ferroptosis in infection, inflammation, and immunity (2021, background): “BMPs belong to the TGFB superfamily, which is involved in regulating cell proliferation, differentiation, and activity of B, natural killer, and myeloid cells (Wang et al., 2014).”
• Large Artery Stiffness in Health and Disease: JACC State-of-the-Art Review (2019, background): “First, diabetic individuals exhibit much higher carotid-femoral PWV than their non-diabetic counterparts,(7) even in the setting of established CKD (42,43) or HFpEF.”
• Silk fibroin as biomaterial for bone tissue engineering. (2016, background): “The delivery of BMP-2 using SF has been extensively evaluated for the application in bone regeneration [155].”
• Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “BMP signaling, which activates SMAD1/5/8 proteins to alter gene expression with co-activator SMAD4 (von Bubnoff and Cho, 2001), affects differentiation of several fibroblast-derived lineages (Wang et al., 2014).”
• Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “TGFβ/BMP can also activate SMAD-independent signaling pathways, including TAK1(TGFβ−activated kinase 1) and ERK1/2 (extracellular signal-regulated kinase 1 and 2).(327,328) A series of studies have shown that TGFβ/BMPs are an indispensable signaling pathway for regulating cartilage homeostasis both ”