Bats host major mammalian paramyxoviruses

By J. Drexler, V. Corman, M. Müller, G. Maganga, Peter Vallo, T. Binger, Florian Gloza-Rausch, Andrea Rasche, S. Yordanov, Antje Seebens and 24 more. Nature Communications, 2012

654 citations recorded by the source corpus.

The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data. The large virus family,Paramyxoviridae, includes several human and livestock viruses. This study, testing 119 bat and rodent species distributed globally, identifies novel putative paramyxovirus species, providing data with potential uses in predictions of the emergence of novel paramyxoviruses in humans and livestock.

Subfields: Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/0e5e300d4ae632a7b5f0d25d8d89eb3cbedc03f4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Yong‐Zhen Zhang
2. A. Cunningham
3. Barney S. Graham

In Infectious Diseases

1. Kwok-Yung Yuen
2. Yong‐Zhen Zhang
3. A. Cunningham
4. C. K. R. Willis
5. Christian Drosten
6. P. Cryan

Citations in the corpus

• Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease (2013, background): “More pneumoviruses remain to be identified: recent wide-ranging fieldwork provided sequence evidence of RSV-like viruses in African bats (Drexler et al. 2012).”
• TAXONOMY OF THE ORDER MONONEGAVIRALES: UPDATE 2016 (2016, background): “The family Paramyxoviridae was emended by expanding the genus Avulavirus by three species (Avian paramyxovirus 10-12 for avian paramyxoviruses 10-12, respectively [5, 19, 28]), the genus Henipavirus by three species (Cedar henipavirus for Cedar virus [17], Ghanaian bat henipavirus for Kumasi virus [”
• Hosts and Sources of Endemic Human Coronaviruses (2018, background): “And third, they should be naturally infected beyond the geographic range of present social groups (Drexler et al., 2012; Greger, 2007; Haydon et al., 2002).”
• A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? (2013, result): “This is supported by the most recent molecular studies that indicate there has been a greater number of host switches of paramyxoviruses from bats to other mammals than from rodents, birds, primates, carnivores and cetartiodactyls [55].”