IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

By A. Boobis, J. Doe, B. Heinrich-Hirsch, M. E. (Bette) Meek, S. Munn, M. Ruchirawat, J. Schlatter, J. Seed, C. Vickers. Critical Reviews in Toxicology, 2008

371 citations recorded by the source corpus.

Subfields: Cancer Research, Chemical Health and Safety, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/0d18a84dc7c3eadd7726a3adb4ec427c0054f576

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. D. Villeneuve
2. D. Crump
3. B. Ossendorp
4. U. Banasiak
5. N. Garcia-Reyero
6. P. Hamey
7. I. Sebestyén
8. A. Boobis

Citations in the corpus

• Cumulative risk assessment of pesticide residues in food. (2008, background): ““Mode of action” refers to the major steps (“key events”) leading to a toxicological effect produced by a compound whereas “mechanism of action” is a detailed explanation of the individual molecular events leading to the toxic effect (Boobis et al., 2006).”
• Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. (2012, neutral): “There is also debate over whether the mechanism (or mode) of action must be explained for each effect to determine whether a relevant pathway is present in humans (616, 617).”
• Adverse outcome pathway (AOP) development I: strategies and principles. (2014, background): “…of a toxicological response and supported by robust weight of evidence, the AOP framework is conceptually synonymous with the Mode of Action framework developed for analyzing the relevance of toxicological effects observed in animals to human health risk assessment (Boobis et al., 2006, 2008).”