Faculty Opinions recommendation of Obesity-associated variants within FTO form long-range functional connections with IRX3.

By S. Malcolm. 2014

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The Post-GWAS Era: From Association to Function. (2018, background): “As the obesity-associated region displays enhancer-associated histone marks, the authors then demonstrated enhancer activity for this region using transgenic mouse assays.(73) Importantly, they also demonstrated an association between the obesity-associated SNPs and IRX3 expression in a large set of”
Rethinking m6A Readers, Writers, and Erasers (2017, background): “However, this view was overturned by several studies that showed that obesity-associated FTO mutations do not affect the FTO protein; instead, such mutations affect the expression of neighboring genes (Claussnitzer et al. 2015, Smemo et al. 2014, Stratigopoulos et al. 2016).”
An expanded view of complex traits: from polygenic to omnigenic (2017, background): “This model has motivated many studies that aim to dissect the functional impacts of individual disease-associated variants (Smemo et al., 2014; Sekar et al., 2016) or to aggregate hits to identify key disease pathways and processes (Califano et al., 2012; Jostins et al., 2012; Wood et al., 2014;…”