Genes expressed in human tumor endothelium.

By B. S. Croix, C. Rago, Victor E. Velculescu, Giovanni Traverso, K. Romans, E. Montgomery, A. Lal, G. Riggins, Christoph Lengauer, Bert Vogelstein and 1 more. Science, 2000

1,902 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0cdf771b93155c26db225ee6993a8a0520d23a5b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. D. Neri
2. Robert B. West
3. Shu Chien
4. Torsten O. Nielsen
5. R. Hynes
6. R. Bicknell
7. Michael Detmar
8. A. Ullrich

In Molecular Biology

1. K. Alitalo
2. J. Chiu
3. Shu Chien
4. D. Neri
5. Patrick O. Brown
6. R. Hynes
7. W. Aird
8. R. Bicknell

Citations in the corpus

• Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. (2013, background): “Ongoing production of angiogenic growth factors in tumors induces profound morphological and molecular changes in tumor blood vessels (Ryschich et al., 2002; St Croix et al., 2000).”
• Nanomedicine: current status and future prospects (2005, background): “Examples include integrins v 3, v 5 and 5 1, which are up-regulated in angiogenic endothelial cells and play a role in the process of angiogenesis (55, 58, 92, 93).”
• Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “The notion of phenotypic diversity of ECs arises from both in vivo (510, 538) and cell culture studies (60, 84, 146, 567), which indicate that there are substantial differences in gene expression between ECs from different vascular sites.”
• The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. (2004, methodology): “In situ hybridization of TMA sections was performed based on a protocol published previously.(23,24) Briefly, digoxigenin-labeled sense and anti-sense RNA probes are generated by polymerase chain reaction amplification of 400- to 600-bp products with the T7 promoter incorporated into the primers.”
• Endothelial cell heterogeneity (2003, background): “Scanning electron microscopy (50–52) Vascular casts (153) Immunohistochemistry (25, 147, 154) En face (Hautchen preparations) (7, 9, 10, 134) In situ hybridization studies (137, 143) Immunization and generation of antibodies (53–58) Radiolabeled antibodies (42, 43, 59) Proteomics Cell surface (membr”
• Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis (2001, methodology): “We verified the specificity of the VE-cadherin antibodies using adjacent, non-vascularized sections that were negative for CD31, vWF and CD146 (ref”
• Specialization of tumour vasculature (2002, neutral): “189::srchform:PDQ:">colon cancers and those from adjacent normal tissu”
• Tumour vascular targeting (2005, methodology): “Following the isolation of endothelium from normal and cancerous colon, SAGE libraries were constructed and a direct comparison identified genes that were upregulated in the tumour endotheliu”
• Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis (2001, methodology): “Non-radioactive in situ hybridization was performed as describe”
• Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms (2004, background): “Moreover, tumor blood vessels and normal blood vessels are characterized by a distinct gene expression pattern, suggesting a distinct target profile when considering anti-angiogenic therapies (49, 50).”