Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
By J. Stevens, O. Blixt, T. Tumpey, J. Taubenberger, J. Paulson, Ian A. Wilson. Science, 2006
991 citations recorded by the source corpus.
Subfields: Agronomy and Crop Science, Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/0b5fb0c878603797e2496767586a2d41101f0e51
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Agronomy and Crop Science
In Epidemiology
In Immunology
Citations in the corpus
- Biological roles of glycans (2016, background): “Much has been written about the specificity of the binding of these pathogens in relation to the sialic acid ligand, particularly the specific linkage to the underlying sugar chain, which determines the preference of the virus for avian versus human hosts (739) (740) (741) (742) (743) (744) (745) (7”
- Synthesis and medical applications of oligosaccharides (2007, background): “The oligosaccharide binding preferences of different types of avian and human influenza strains can be determined using carbohydrate microarray”
- Sialic acids in human health and disease (2008, positive): “There is now evidence that a direct bird to human transfer did occur at least once before, when the infamous 1918 influenza pandemic killed tens of millions of people [83,84].”
- Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses (2009, neutral): “We expressed recombinant trimeric ectodomain of H5 hemagglutinin from one of these viruses (strain A/Vietnam/1203/04 (H5N1), 'H5-VN04', clade 1) in insect cell”
- H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice (2008, background): “While the importance of the binding properties of the HA molecule has been demonstrated elsewhere extensively [22,40,41], further resolution of this interesting finding and its immunological importance deserves further experimentation.”
- Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “Novel technologies such as glycan microarrays are revealing that the situation is indeed complex, with different virus strains binding to novel structures such as sulfated and sialylated glycans in addition to the conventional SA -2,3 and SA -2,6 (57, 212, 213).”
- Influenza A viruses: new research developments (2011, background): “Mutations G225D and E190D reduced the avidity of an HPAI H5N1 virus to α-2,3-SA, but α-2,6-SA specificity was not favoure”