Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction

By T. Ide, Hiroyuki Tsutsui, Shunji Hayashidani, D. Kang, Nobuhiro Suematsu, Kei-ichiro Nakamura, H. Utsumi, N. Hamasaki, Akira Takeshita. Circulation Research, 2001

684 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/0b5c3af97d8b6a6fd5a50e5860b53dd313397564

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Rong Tian
2. Bo Zhou

In Molecular Biology

1. Rong Tian
2. N. Perron
3. Julia L Brumaghim

In Pathology and Forensic Medicine

1. N. Perron
2. Julia L Brumaghim

Citations in the corpus

• Mitochondrial dysfunction in pathophysiology of heart failure (2018, background): “Increased oxidative stress is associated with mtDNA damage and impaired mitochondrial biogenesis (120, 137).”
• A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding (2009, background): “Oxidative DNA damage has been implicated as a cause of cancer [48, 49], aging and neurodegenerative diseases such as Alzheimer’s and Parkinson’s [50–54], cardiovascular diseases such as arteriosclerosis [55, 56], and is the primary cause of cell death and tissue damage resulting from heart attack an”
• Mitochondrial function as a therapeutic target in heart failure (2016, neutral): “Heightened mitochondrial ROS production and downstream ROS-mediated damage has been reported in patients with HF as well as in preclinical models of the disease 31,99–101 .”