Engineered nanoparticles for drug delivery in cancer therapy.

By Tianmeng Sun, Yu Zhang, Bo Pang, D. Hyun, Miaoxin Yang, Younan Xia. Angewandte Chemie, 2014

1,900 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0401ac950473f8afecb7a25a7e565bde798a3753

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Citations in the corpus

Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. (2016, methodology): “020 intended target and are sequestered by the liver and spleen (if N6 nm) or eliminated though the kidney (if b6 nm) after administration into the body [2,4].”
A review on nanoparticles: characteristics, synthesis, applications, and challenges (2023, background): “The particles can be used in biomedical applications such as cancer treatment (Sun et al., 2014), biological imaging (Abdulle and Chow, 2019), chemical sensing, and drug delivery.”
The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment (2020, background): “As the efficacy of traditional anti-tumor drugs, such as chemotherapeutic or immunomodulatory agents, has been restricted by the ECM barriers which limit the diffusion of drugs [71], CAF-targeted nanoparticles used in remodeling TME have attracted great attention (Table 1).”
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors (2017, background): “A number of nanocarrier-based products have been approved for the treatment of various tumors, and many others are in different phases of clinical trials.(4) In the current review, we first discussed features of different types of nanocarriers (organic, inorganic and hybrid) along with their relevan”
Application of Light Scattering Techniques to Nanoparticle Characterization and Development (2018, background): “With nanoparticles activity being dependent of their physicochemical properties, namely size, shape, and surface, their toxicity toward cells is also dependent of these properties (Bera et al., 2014; Sun et al., 2014; Rajchakit and Sarojini, 2017).”
Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies. (2016, background): “Examples of NPs include polymers, solid lipids, metals, quantum dots, dendrimers, liposomes, and micelles (BarZeev et al., 2016; Livney and Assaraf, 2013; Shapira et al., 2012; Sun et al., 2014; Yang et al., 2016; Zhang and Akbulut, 2011).”
Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model (2019, background): “However, IKE NP-treated mice had a similar weight compared with the saline vehicle and the NP vehicle groups; the lower toxicity of the IKE NP formulation might result from the NPs’ capability to prevent the aggregation of hydrophobic drugs (Sun et al., 2014), or the NP EPR effect, which decreases t”
Nanocomposite Hydrogels: 3D Polymer-Nanoparticle Synergies for On-Demand Drug Delivery. (2015, background): “as advanced systems with the promise of delivering drugs to target cells, especially in cancer therapy.(2) However, clinical applica-”
Liposomes: structure, composition, types, and clinical applications (2022, background): “Liposomes are spherical lipid vesicles (usually 50–500 nm in diameter particle size) composed of one or more lipid bilayers, as a result of emulsifying natural or synthetic lipids in an aqueous medium [12, 13] (Figure 1).”
Cancer nanomedicine: a review of recent success in drug delivery (2017, background): “the scheme of cores and branching units, the molecular weight, size, branch density, flexibility, and water solubility can be specified [49].”