Sharpening high resolution information in single particle electron cryomicroscopy.

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Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix (2019, background): “However, sharpening can reveal the high-resolution details concealed in a cryo-EM map (Rosenthal & Henderson, 2003; Fernández et al., 2008).”
Blind deconvolution in scientific imaging & computational photography (2011, methodology): “For comparison we also show the results of B-factor sharpening, where we used the implementation of Fernández et al. (2008). The resulting density is of poor quality, which is probably due to unwanted noise amplification.”
One number does not fit all: mapping local variations in resolution in cryo-EM reconstructions (2013, methodology): “Furthermore, the same information can be used to determine the equivalent B-factors and to sharpen the reconstruction in a localized manner, following available methods (Fernandez et al., 2008; Rosenthal and Henderson, 2003) that use resolution curves to determine optimum parameters.”