Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2

By M. King, J. Marks, Jessica B Mandell. Science, 2003

2,115 citations recorded by the source corpus.

Subfields: Genetics, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/0ad6d088c59b8c1e10474424669cf9038f4f1ce0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Terrie E. Moffitt
2. Avshalom Caspi
3. A. D’Andrea
4. Gad Getz
5. Stacey Gabriel
6. M. Jasin
7. M. Matzuk
8. M. King

In Reproductive Medicine

1. A. D’Andrea
2. Ankur K. Nagaraja
3. M. Matzuk
4. Raphael Ceccaldi
5. M. Edson

Citations in the corpus

• Homologous recombination deficiency: Exploiting the fundamental vulnerability of ovarian cancer (2015, background): “Patients with germline BRCA1/2 mutations are associated with the hereditary breast/ovarian cancer syndrome, which is characterized by familial clustering of breast and ovarian tumors (40).”
• Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. (2006, background): “Risks for young women with inherited BRCA1 or BRCA2 mutations are particularly increased.(1) Among white women in the United States, 5% to 10% of breast cancer cases and 10% to 15% of ovarian cancer cases are due to inherited mutations in BRCA1 and BRCA2.”
• Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. (2012, positive): “Germline BRCA1/BRCA2 mutations are associated with increased response rates to chemotherapy and overall survival (32).”
• The mammalian ovary from genesis to revelation. (2009, background): “Loss of function germline mutations in the tumor suppressor BRCA1 account for 90% of these cases and are highly penetrant, conferring a 40–60% lifetime risk of developing ovarian cancer, compared with 1–2% in the general population (517, 518).”
• Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “%) cancer (average cumulative risks by age 70), as well as a lesser increase in risk for pancreatic, prostate, and other cancers (King et al. 2003; Metcalfe et al. 2010).”
• Gene–environment interactions in psychiatry: joining forces with neuroscience (2006, background): “This pathogenesis hypothesis is under study in relation not only to mental disorders, but also to cance”
• Cell-cycle checkpoints and cancer (2004, background): “From BRCA to p53 to cancer The inheritance of a single mutated allele of either BRCA1 or BRCA2 markedly increases the incidence of breast and ovarian cancers in wome”
• From cancer patient to cancer survivor : lost in transition (2006, background): “Women with BRCA1 and BRCA2 mutations who do not undergo prophylactic surgery have a risk of breast cancer of 45 to 84 percent by age 70 (Ford et al., 1998; Antoniou et al., 2003; King et al., 2003; Easton et al., 2004).”