A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding

By Qilai Huang, Thomas Whitington, P. Gao, J. Lindberg, Yuehong Yang, Jielin Sun, Marja-Riitta Väisänen, R. Szulkin, Matti Annala, Jian Yan and 12 more. 2014

213 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pulmonary and Respiratory Medicine

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Chen-Plotkin
2. M. Gallagher
3. R. DePinho

In Molecular Biology

1. A. Chen-Plotkin
2. Dongwon Lee
3. Michael A. Beer
4. M. Gallagher
5. R. DePinho

Citations in the corpus

• The Post-GWAS Era: From Association to Function. (2018, background): “Some studies have functionally linked expression levels of the causative gene to disease-relevant phenotypes, but many of these studies relied upon imprecisely-controlled overexpression, strong knockdown, or knockout approaches.(35,64,73,91) Recapitulating the gene-expression differences relevant to”
• Genetics and biology of prostate cancer (2018, background): “Specifically, epidemiological studies have established that a family history of prostate cancer significantly increases risk (Goldgar et al. 1994; Lange 2010); twin studies have indicated that prostate cancer is among themost heritable cancers (Lichtenstein et al. 2000); GWASs have identifiedmany pr”
• A method to predict the impact of regulatory variants from DNA sequence (2015, background): “…validated SNPs, each of which has been shown to alter expression, thereby leading to increased disease risk or pertinent traits, for RFX6 (rs339331; prostate cancer) 25 , BCL11A (rs1427407; fetal hemoglobin levels) 26 and SORT1 (rs12740374; low-density lipoprotein (LDL) cholesterol levels) 27 .”