Histone deacetylases, transcriptional control, and cancer

By W. Cress, E. Seto. Journal of Cellular Physiology, 2000

661 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0a26cbe217eab8a005b26b05dc2a7e15845ecaf2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. E. Seto
2. Xiang-Jiao Yang
3. G. Semenza
4. Minoru Yoshida
5. PA Marks
6. T. Jenuwein
7. D. O’Carroll
8. W. Wright

Citations in the corpus

• FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. (2001, background): “VHL and FIH-1 interact with histone deacetylases in vitro A general property of corepressors is the recruitment of histone deacetylases (HDACs) to DNA-binding transcription factors (for reviews, see Semenza 1998; Cress and Seto 2000).”
• Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression (2002, background): “A variety of transcription factors including Rb, Mad, unliganded nuclear hormone receptors and p53 have been shown to regulate target genes by association with HDAC1 (reviewed in Cress and Seto, 2000; Ng and Bird, 2000).”
• Human Telomerase and Its Regulation (2002, background): “Mad1 has been shown to interact with mammalian Sin3, which associates with HDAC1, HDAC2, and a nuclear hormone transcriptional corepressor called NcoR (nuclear corepressor) (42).”
• Erasers of histone acetylation: the histone deacetylase enzymes. (2014, background): “This is the case for mutations in several oncogenic proteins generated by chromosome translocation such as PML-RARa and AML1-ETO fusion proteins that recruit HDACs (reviewed by Cress and Seto 2000).”
• Histone Deacetylase Inhibitors: Overview and Perspectives (2007, background): “Alterations in both histone acetyltransferases and HDACs are found in many human cancers (1, 2, 5, 26-34).”
• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, positive): “In humans, members of the classical family include HDAC1, -2, -3 and -8 (class I); HDAC4, -5, -6, -7, -9 and -10 (class II); and HDAC11 (class IV) (reviewed by Cress and Seto, 2000; Grozinger and Schreiber, 2002; Blander and Guarente, 2004; Gregoretti et al., 2004).”