Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.

By F. Heller, I. Fuss, E. Nieuwenhuis, R. Blumberg, W. Strober. Immunity, 2002

640 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/0a1e581e56724af7cc72b19ea4b3f8ff07aed9b2

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In Immunology

1. Q. Guan
2. D. Godfrey
3. M. Kronenberg
4. J. Turner
5. F. Powrie
6. W. Strober
7. D. Artis

Citations in the corpus

• A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “In consistent with this, deficiency of CD1d and NKT cell prevents the development of oxazolone-induced murine colitis, resembling ulcerative colitis [109].”
• Tight Junction Pore and Leak Pathways: A Dynamic Duo (2011, background): “In contrast to TNF, interleukin (IL)-13, which is also implicated in inflammatory bowel disease, increases paracellular permeability to small, uncharged molecules and cations in vitro and in vivo (16, 62, 127).”
• A guide to histomorphological evaluation of intestinal inflammation in mouse models. (2014, methodology): “As for 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone; Sigma-Aldrich) colitis, again wildtype mice were sensitized with 3% oxazolone and intrarectally challenged with 1% oxazolone after 5 days [14].”
• The immunological and genetic basis of inflammatory bowel disease (2003, background): “Recently, it has been shown that oxazolone-induced colitis results from the induction of natural-killer T (NKT) cells that produce IL-13, and that elimination of NKT cells or blockade of IL-13 — by an IL-13 receptor α2 (IL-13Rα2)–immunoglobulin fusion protein — prevents the development of coliti”
• Going both ways: immune regulation via CD1d-dependent NKT cells. (2004, background): “Interestingly, NKT cells were required, even in the absence of α-GalCer activation, for colitis induced by the hapten oxazalone (84), and NKT cell–derived”
• Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis (2008, background): “The IL-13 could be sourced from natural killer T cells, which have been shown to produce IL-13 in UC [50], and in oxazolone-induced colitis in mice, which is considered a UC-like model [53], or from natural killer cells, which are known to produce IL-13 in the intestine during some infections [54].”