A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

By J. Piel. Proceedings of the National Academy of Sciences of the United States of America, 2002

603 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/09d61977679346ab410e8142dd7406b50fc6dd6d

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Citations in the corpus

Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts. (2006, background): “…aromatic polyketides (e.g. monooxygenases involved in biosynthesis or modification of oxytetracycline (Yang et al., 2004), rifampin (Andersen et al., 1997), mithramycin (Prado et al., 1999), chromomycin (Menendez et al., 2004), auricin (Novakova et al., 2005), and griseorhodin (Li and Piel, 2002)).”
Genomic islands in pathogenic and environmental microorganisms (2004, background): “A polyketide operon that contains genes that are involved in the synthesis of the anti-tumour compound pederin is located on a classical symbiosis island in bacterial endosymbionts that reside in beetle”
Metagenomics: genomic analysis of microbial communities. (2004, background): “This has proved effective to identify phylogenetic anchors and genes encoding enzymes with highly conserved domains (81).”
Multiorganismal Insects: Diversity and Function of Resident Microorganisms (2014, background): “A different group of toxins, polyketides, has been implicated in the Pseudomonas-mediated protection of Paederus rove beetles against predators (89) and in an undefined protective role of Profftella armatura, localized in the bacteriocytes of Asian citrus psyllid Diaphorina citri (81).”
Defensive symbiosis in the real world – advancing ecological studies of heritable, protective bacteria in aphids and beyond (2014, background): “The causative agent is a polyketide amide called pederin produced by the Pseudomonas symbiont (Piel 2002).”
Defensive microbial symbionts in Hymenoptera (2014, background): “The symbiont genome encodes a mixed polyketide synthase/non-ribosomal peptide synthetase gene cluster (Piel 2002) that is responsible for the production of the toxin pederin (Kellner 2001; 2002), which deters wolf spiders as potential predators of the beetle larvae (Kellner & Dettner 1996).”
Metagenomics: Application of Genomics to Uncultured Microorganisms (2004, methodology): “Functional screens have identified new enzymes (39, 52, 53, 67, 68, 72, 73, 88, 93, 104, 118, 122, 124, 144) and antibiotics (22, 23, 39, 61, 69, 91, 110, 118, 146) and other reagents in libraries from diverse environments.”