The topology of drug-target interaction networks: implicit dependence on drug properties and target families.

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ChemProt: a disease chemical biology database (2010, background): “For example, celecoxib, often considered a selective cyclooxygenase-2 non-steroidal anti-inflammatory drug (NSAID), has been documented to be active on at least two additional targets, namely carbonic anhydrase II and 5-lipoxygenase (3).”
Virtual screening strategies in drug discovery: a critical review. (2013, background): “It was recently observed that many if not even all drugs bind to several targets (called polypharmacology) which has a clear relevance for the therapeutic action of the drugs and/or for the side effects [161].”
Accurate and efficient target prediction using a potency-sensitive influence-relevance voter (2015, unknown): “Mol-ecules were described as sets of low-dimension descriptors called SHED [23].”
SwissTargetPrediction: a web server for target prediction of bioactive small molecules (2014, background): “For instance, a recent study on a set of 802 drugs and interaction data assembled from seven different databases has shown that known drugs have on average six molecular targets on which they exhibit activity (12).”