Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
By Struan F. A. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, J. Sainz, Agnar Helgason, Hreinn Stefansson, V. Emilsson, A. Helgadóttir and 19 more. Nature Genetics, 2006
2,333 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/084fbed8fd376f39c22a32988634c3e604c752cc
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Citations in the corpus
- Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer (2007, methodology): “For Iceland 2, which was not typed with a genome-wide set of markers, the inflation factor was estimated by simulating genotypes through the Icelandic genealog”
- TNF-α and adipocyte biology (2007, background): “in the TCF7L2 gene and type 2 diabetes [161,162].”
- Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups (2010, background): “With the exception of the KCNQ1 locus which was identified in the Japanese population [1,2], all of the well-replicated risk variants were first identified in populations of Northern European ancestry [3–13].”
- Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico (2013, background): “Multiethnic Cohort (MEC) Los Angeles, California, USA Case–control Controls 2,143 (2,464) 48.”
- Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes (2012, neutral): “Other genes with variants associated with reduced insulin secretion in diabetic patients include TCF7L2 ([497]; transcription factor 7-like 2), SLC30A8 ([498, 499]; solute carrier family 30; zinc transporter, member 8), and CDKAL1 ([500]; CDK5 regulatory subunit associated protein 1-like 1) [495].”