Functional Attachment of Soft Tissues to Bone: Development, Healing, and Tissue Engineering
By Helen H. Lu, S. Thomopoulos. Annual Review of Biomedical Engineering, 2013
420 citations recorded by the source corpus.
Connective tissues such as tendons or ligaments attach to bone across a multitissue interface with spatial gradients in composition, structure, and mechanical properties. These gradients minimize stress concentrations and mediate load transfer between the soft and hard tissues. Given the high incidence of tendon and ligament injuries and the lack of integrative solutions for their repair, interface regeneration remains a significant clinical challenge. This review begins with a description of the developmental processes and the resultant structure-function relationships that translate into the functional grading necessary for stress transfer between soft tissue and bone. It then discusses the interface healing response, with a focus on the influence of mechanical loading and the role of cell-cell interactions. The review continues with a description of current efforts in interface tissue engineering, highlighting key strategies for the regeneration of the soft tissue–to-bone interface, and concludes with a summary of challenges and future directions.
Subfields: Orthopedics and Sports Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/080737d59df2790d23be91dbaed5ff4750f2471b
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Citations in the corpus
- Functional gradients and heterogeneities in biological materials: Design principles, functions, and bioinspired applications (2017, background): “, the tendon and ligament tissues that attach muscle to bone and bone to bone, respectively [127,128].”