Ribosome-targeting antibiotics and mechanisms of bacterial resistance
By Daniel N. Wilson. Nature Reviews Microbiology, 2013
959 citations recorded by the source corpus.
Subfields: Infectious Diseases, Molecular Biology, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/07f212203022da4f20ef18338322adf98f5a29cf
How researchers see this paper
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In Infectious Diseases
In Molecular Biology
- James J. Collins
- Ahmad S. Khalil
- Daniel J. Dwyer
- T. Foster
- Roland Beckmann
- J. Munita
- C. Arias
- O. Berninghausen
In Molecular Medicine
Citations in the corpus
- Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 (2020, background): “Ribosomes are established targets of a plethora of small molecules such as antibiotics ( 45 ), and to the best of our knowledge, the pocket on h18 is not used by any host factor during normal translation or ribosome biogenesis.”
- Aminoglycosides: An Overview. (2016, background): “Some aminoglycosides can also impact protein synthesis by blocking elongation or by directly inhibiting initiation (Davis 1987; Kotra et al. 2000; Wilson 2014).”
- Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes. (2017, background): “Many ligand complexes of the ribosome have been studied by X-ray crystallography (reviewed by [49]).”
- Mechanisms of Antibiotic Resistance (2016, background): “Inter-estingly, most of the antibiotics affected by these enzymatic modi fi cations exert their mechanism of action by inhibiting protein synthesis at the ribosome level (11).”
- Antibiotic efficacy is linked to bacterial cellular respiration (2015, background): “Interestingly, the majority of bacteriostatic antibiotics inhibit protein production (42), which as a process is the largest single consumer of total metabolic output (23, 43).”
- Antibiotic resistance in Staphylococcus aureus. Current status and future prospects (2017, background): “X-ray crystallography of ribosomes in complex with antibiotics has revealed important details of drug binding sites and has provided mechanistic explanations for their inhibitory action (Wilson 2009, 2014; Arenz and Wilson 2016; Walsh 2016).”