Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

By R. Postuma, J. Gagnon, M. Vendette, M. Fantini, J. Massicotte‐Marquez, J. Montplaisir. Neurology, 2009

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Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease (2012, background): “Rapid eye movement sleep behavior disorder (RBD) is also believed to precede PD by a number of years.(45,46) Currently, no observational studies that give ORs or RRs for this association have been reported.”
Epidemiology and etiology of Parkinson’s disease: a review of the evidence (2011, background): “Neurodegenerative diagnoses included PD, LBD, Alzheimer’s disease, and MSA [523].”
Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease (2012, background): “As of 2011, the largest reported cohort of idiopathic RBD is 93 patients.(52) This is a major challenge to those who would wish to identify RBD patients for neuroprotective therapy.”
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. (2013, result): “The striking finding from this study and from studies by the Barcelona and Montreal groups [28,29] is that iRBD in middle aged and older adults commonly heralds future parkinsonism.”
Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study (2019, background): “In their 2009 report, which included patients followed clinically/ ad hoc, conversion risk at 5 years was 18% (Postuma et al., 2009).”