Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study

By R. Postuma, Á. Iranzo, M. Hu, B. Högl, Brad Boeve, R. Manni, W. Oertel, I. Arnulf, L. Ferini-Strambi, M. Puligheddu and 45 more. Brain : a journal of neurology, 2019

966 citations recorded by the source corpus.

See Morris and Weil (doi:10.1093/brain/awz014) for a scientific commentary on this article. In a prospective multicentre study involving 1280 patients with idiopathic RBD, Postuma et al. show that approximately 6% of patients each year (>73.5% over 12 years) convert to full neurodegenerative disease. They test the predictive power of 21 prodromal markers of neurodegeneration, providing a template for planning neuroprotective trials.

Subfields: Cognitive Neuroscience, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/e6dc38621daa38dc7c0783eb8b7335bbd092e5ca

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1. J. Horsager
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Citations in the corpus

• Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study. (2020, background): “It is known that iRBD patients convert to approximately equal numbers of Parkinson’s disease and DLB cases (Postuma et al., 2019).”