Inflammatory Myofibroblastic Tumor: Comparison of Clinicopathologic, Histologic, and Immunohistochemical Features Including ALK Expression in Atypical and Aggressive Cases

By C. Coffin, J. Hornick, C. Fletcher. American Journal of Surgical Pathology, 2007

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Inflammatory myofibroblastic tumours: where are we now? (2007, background): “28 30 However, dedifferentiated liposarcoma usually presents in an older age group than IMT, and adequate sampling of the mass and adjacent soft tissue will usually reveal a higher grade component and/or areas of well-differentiated liposarcoma.”
The anaplastic lymphoma kinase in the pathogenesis of cancer (2008, background): “These mesenchymal tumours are composed of neoplastic spindle cells mixed with a reactive inflammatory infiltrate of lymphocytes and plasma cell”
Mechanisms of receptor tyrosine kinase activation in cancer (2018, positive): “Most notably, ALK rearrangements occur in approximately 3–7% of NSCLCs [104], approximately 50% of all inflammatory myofibroblastic tumors (IMTs) [105, 106], 10% of Spitzoid neoplasms [107], as well as small percentages in colon cancer [94, 108, 109], thyroid cancer [94, 110], and several other type”