Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

By S. Turajlic, Hang Xu, K. Litchfield, A. Rowan, T. Chambers, J. López, D. Nicol, T. O'brien, J. Larkin, S. Horswell and 39 more. Cell, 2018

734 citations recorded by the source corpus.

Summary Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases.

Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/234df0ec591a2ac93e7b73fe2649e17488dc1a3b

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In Cancer Research

  1. W. Marston Linehan
  2. Eric E. Schadt
  3. A. Robles
  4. Arul M. Chinnaiyan
  5. Antonio Colaprico
  6. Xi Chen
  7. M. Wiznerowicz
  8. A. Krek

In Molecular Biology

  1. Alexey I. Nesvizhskii
  2. Dmitry Avtonomov
  3. Andy T. Kong
  4. W. Marston Linehan
  5. Eric E. Schadt
  6. A. Robles
  7. Bing Zhang
  8. Arul M. Chinnaiyan

In Pulmonary and Respiratory Medicine

  1. Arul M. Chinnaiyan

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