Structural determinants of nuclear receptor assembly on DNA direct repeats

By F. Rastinejad, T. Perlmann, R. Evans, P. Sigler. 1995

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The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed (1998, methodology): “(TR)-RXR on a thyroid hormone responsive element (TRE)((102)) provides an initial approximation of VDR struc-”
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. (1999, background): “…to a DNA half-site, the structure is induced and stabilized in the region of the protein that forms the dimerization interface (Holmbeck et al., 1998b); the induced structure is very similar to that seen in the X-ray structure of the RXR-TR heterodimer assembled on DNA (Rastinejad et al., 1995).”
Overview of Nomenclature of Nuclear Receptors (2006, background): “As seen in the crystal structures of NR DBDs bound to DR elements, the receptors bind as “head-to-tail” heterodimers (Rastinejad et al., 1995, 2000; Zhao et al., 2000; Shaffer and Gewirth, 2002).”
Nuclear hormone receptors and gene expression. (2001, background): “In contrast to the head-to-head arrangement of steroid receptor DBDs on DNA, the X-ray structure of the RXR/TR heterodimer reveals a polar head-to-tail assembly of the two proteins on a DR4, with RXR indeed occupying the upstream motif (212).”