Crystal structure of the human β2 adrenergic G-protein-coupled receptor

By S. Rasmussen, Hee-Jung Choi, D. Rosenbaum, T. S. Kobilka, Foon Sun Thian, P. Edwards, M. Burghammer, Venkata R. P. Ratnala, R. Sanishvili, R. Fischetti and 3 more. 2007

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Subfields: Cellular and Molecular Neuroscience, Molecular Biology

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Citations in the corpus

Improving homology modeling from low-sequence identity templates in Rosetta: A case study in GPCRs (2020, background): “Therefore, it wasn’t until 2007 that the structure of a second receptor was experimentally determined [5,6].”
3D structures of membrane proteins from genomic sequencing (2012, neutral): “…experimental methods (Chen et al., 2010; Cherezov et al., 2007; Choe et al., 2011; Long et al., 2007; Miller and Long, 2012; Rasmussen et al., 2011; Rasmussen et al., 2007), the 3D structures of most transmembrane proteins remain unknown, and comparative modeling maximally covers 10% of all human…”
Outcome of a Workshop on Applications of Protein Models in Biomedical Research (2009, background): “Clearly, the recent GPCR structures (Cherezov et al., 2007; Rasmussen et al., 2007; Warne et al., 2008) will further aid modeling of this important class of biological targets.”
Structure-based drug discovery and protein targets in the CNS. (2011, methodology): “This was achieved initially for the human beta adrenergic receptor b2AR by either complexing with an antibody bound (Rasmussen et al., 2007), or insertion of T4 lysozyme (Cherezov et al., 2007).”
GPCR-I-TASSER: A hybrid approach to G protein-coupled receptor structure modeling and the application to the human genome (2015, background): “Signiﬁcant efforts have been made on the technical improvement of GPCR expression and crystallization, which resulted in successful solution of 15 human GPCRs in the last 8 years since 2007 (Jaakola et al., 2008; Rasmussen et al., 2007).”
Lifting the lid on GPCRs: the role of extracellular loops (2011, background): “The first crystal structure reported for the inactive conformation of a GPCR with a diffusible ligand utilized a monoclonal Fab fragment to stabilize a carazolol-b2AR complex (Rasmussen et al., 2007).”
The Bio3D packages for structural bioinformatics (2020, background): “Representative structures are from PDB 2R4R (for Group 1), 30 which is a structure bound with an inverse agonist and so representing the inactive state of the GPCR, and PDB 3SN6 (for Group 2), 28 an activated GPCR structure.”
PDBe: improved accessibility of macromolecular structure data from PDB and EMDB (2015, background): “This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. to more recently with st”