Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy

By E. Carro, J. Trejo, S. Busiguina, I. Torres-Alemán. Journal of Neuroscience, 2001

636 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Endocrinology, Diabetes and Metabolism, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/072b54032b6be323afa9651f409bcfbf377bc437

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. M. Schwartz
2. G. Martino
3. L. Bonfanti
4. S. Pluchino

In Molecular Biology

1. M. Schwartz
2. G. Martino
3. Volkmar Lessmann
4. L. Bonfanti
5. S. Pluchino
6. A. Maass

Citations in the corpus

• Epidemiology of Alzheimer Disease (2012, neutral): “It may also increase neuronal survival and resistance to brain insults (Carro et al. 2001), increase levels of brainderived neurotrophic factor, mobilize gene expression profiles that would be predicted to benefit brain plasticity (Cotman and Berchtold 2002), and reduce levels of C-reactive protein…”
• Positive effect of acute mild exercise on executive function via arousal-related prefrontal activations: An fNIRS study (2014, background): “, 2007) and functions, such as neurogenesis and spatial memory, without a stress response (Carro et al., 2001; Okamoto et al., 2012).”
• The Influence of Exercise on Cognitive Abilities (2013, neutral): “neurotransmitter synthesis, and release (2), and can support cognitive function (20, 154).”
• Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults (2016, methodology): “Brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I), and vascular endothelial growth factor (VEGF) are currently considered as key proteins that are up-regulated after exercise (Carro et al., 2001; Fabel et al., 2003; Neeper et al., 1995) and that can promote cell prolifer”
• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Importantly, many of these microglia secrete insulin-like growth factor (IGF)-I, a growth factor known to be important for neurogenesis and neuroprotection (39, 233).”