When Not Enough Is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-Related Disorders

By Charles L Raison, Andrew H. Miller. 2003

673 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/070ba255219619885b1ec24b4f741714558a0cb0

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In Behavioral Neuroscience

In Biological Psychiatry

In Endocrinology, Diabetes and Metabolism

Citations in the corpus

Epigenetics and the biological definition of gene x environment interactions. (2010, background): “…important to note that insufficient activation of defensive responses under conditions of threat also compromises health and is associated with chronic fatigue, chronic pain, posttraumatic stress disorder, and hyperinflammation (Munck et al., 1984; Raison & Miller, 2003; Yehuda & Bierer, 2008).”
Health psychology: developing biologically plausible models linking the social world and physical health. (2009, background): “…interfering with the ability of cortisol to deliver signals to white blood cells, stressors may facilitate the kinds of proinflammatory gene expression cascades that contribute to coronary disease, autoimmune disorders, and infectious diseases (also see Miller et al. 2002a, Raison & Miller 2003).”
The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “Depression is often associated with hypercortisolemia and glucocorticoid resistance (Raison and Miller, 2003).”
Sex differences in HPA axis responses to stress: a review. (2005, background): “…HPA axis is associated with manifestations of psychosomatic and psychiatric disorders (for reviews, see Chrousos and Gold, 1992; Heim et al., 2000a,b; Holsboer, 1989; Raison and Miller, 2003; Stratakis and Chrousos, 1995; Tsigos and Chrousos, 1994; Tsigos and Chrousos, 2002; Young, 1998).”
Depressive disorders and immunity: 20 years of progress and discovery. (2007, background): “…inflammation, cytokine-induced disruption of GR function may lead to a feed-forward cascade in which increasing inflammation leads to increased glucocorticoid resistance which in turn leads to reduced glucocorticoidmediated feedback inhibition of inflammatory responses (Raison and Miller, 2003).”
Cytokines and their relationship to the symptoms and outcome of cancer (2008, background): “In stress-related neuropsychiatric disorders there is evidence of abnormal glucocorticoid signallin”
Athlete burnout: an integrated model and future research directions (2011, background): “Changes in HPA axis function have been found in many stress-related disorders (Raison & Miller, 2003 ) including chronic fatigue syndrome (Parker, Wessely, & Cleare, 2001 ) and overtraining syndrome (Steinacker & Lehmann, 2002 ).”