Suppression of Aging in Mice by the Hormone Klotho

By H. Kurosu, Masaya Yamamoto, Jeremy D. Clark, J. Pastor, A. Nandi, Prem Gurnani, O. McGuinness, H. Chikuda, M. Yamaguchi, H. Kawaguchi and 6 more. Science, 2005

1,897 citations recorded by the source corpus.

Subfields: Genetics, Nephrology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/0703270e55233556fbc2a79631261df12bcd631d

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Citations in the corpus

The FGF family: biology, pathophysiology and therapy (2009, neutral): “Overexpression of Kl can extend the lifespan of mic”
Metabolic Control of Longevity. (2016, background): “Conversely, transgene-driven Kl overexpression extends lifespan (Kurosu et al., 2005), and recombinant Kl injection into mice promotes cytoprotective autophagy (Shi et al., 2015).”
Programming the magnitude and persistence of antibody responses with innate immunity (2011, neutral): “vector RIG 0 2 4 6 vector KLm (1-1012) KLs (1-549) KLsss (34-549)”
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “Emerging interest is on klotho as a new anti-aging gene, since its overexpression extends lifespan by 20-30% [265] and could protect the”
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. (2006, background): “…of genes involved in control of mutation rate, regulation of chromosome and telomere stability, ROS homeostasis, apoptosis, stress responses, and the insulin/IGF pathway (Tyner et al. 2002; Mounkes et al. 2003; Chang et al. 2004; Trifunovic et al. 2004; Kujoth et al. 2005; Kurosu et al. 2005).”
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010, background): “Disruption of the Klotho gene causes a premature aging phenotype (12), whereas transgenic mice that overexpress Klotho exhibit increased resistance to oxidative stress (13) and a significant extension of lifespan (14).”