Understanding the tumor immune microenvironment (TIME) for effective therapy

By M. Binnewies, Edward W. Roberts, K. Kersten, Vincent Chan, Douglas Fearon, Miriam Merad, Lisa M. Coussens, D. Gabrilovich, S. Ostrand-Rosenberg, C. Hedrick and 8 more. Nature Medicine, 2018

5,098 citations recorded by the source corpus.

The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have experienced minimal or no clinical benefit when provided the same treatment. As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation and response and therapy; by parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed. The tumor immune microenvironment influences tumor progression and response to immunotherapy; its further characterization will improve therapeutic outcome.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/06febcc524a27ed35cf8040fefe6ed9dcb4d9410

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Citations in the corpus

Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, background): “Organization of these components at the cellular and tissue levels plays a crucial role in the effectiveness of antitumor immunity (Binnewies et al., 2018).”
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020, neutral): “First, the tumor microenvironment and its constituent cellular interactions—accessible to HTAN through spatial and single-cell approaches—represent remarkable targeting opportunities for therapy (Binnewies et al., 2018; Galon and Bruni, 2019; Sharma et al., 2017).”
Dysfunctional CD8+ T cells form a proliferative, dynamically regulated compartment within human melanoma (2018, positive): “The presence of various myeloid cell populations has previously been suggested as a potential modifier of T cell activity in tumors (Binnewies et al., 2018; Lavin et al., 2017; Salmon et al., 2016).”
Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “Also, terms of immunologically “hot” or “inflamed” tumor microenvironments are being coined primarily for tumors which have high levels of infiltrating T cells and increased presence of other components required for antitumor immune function, whereas immunologically “cold”, “infiltration-excluded”, ”