Reinforcement signaling in Drosophila; dopamine does it all after all

By S. Waddell. 2013

254 citations recorded by the source corpus.

Reinforcement systems are believed to drive synaptic plasticity within neural circuits that store memories. Recent evidence from the fruit fly suggests that anatomically distinct dopaminergic neurons ultimately provide the key instructive signals for both appetitive and aversive learning. This dual role for dopamine overturns the previous model that octopamine signaled reward and dopamine punishment. More importantly, this anatomically segregated double role for dopamine in reward and aversion mirrors that emerging in mammals. Therefore, an antagonistic organization of distinct reinforcing dopaminegic neurons is a conserved feature of brains. It now seems crucial to understand how the dopaminergic neurons are controlled and what the released dopamine does to the underlying circuits to convey opposite valence.

Subfields: Cellular and Molecular Neuroscience, Ecology, Evolution, Behavior and Systematics, Genetics

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Ecology, Evolution, Behavior and Systematics

In Genetics

Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “Distinct subsets of DANs are sufficient to drive learned olfactory associations (Aso et al., 2012; Claridge-Chang et al., 2009; Liu et al., 2012; Waddell, 2013; Yamagata et al., 2015), leading to the suggestion they may act autonomously to encode the rewarding or punishing contextual stimuli that…”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “The DANs are the most prevalent modulatory neurons in the MB and dopamine is thought to act locally to modify KC–MBON synapses (Aso et al., 2010; Waddell, 2013).”
Reward signal in a recurrent circuit drives appetitive long-term memory formation (2015, unknown): “Dopamine has been thought to simply relay rewarding or punitive stimuli (Gerber et al., 2004; Waddell, 2013).”
Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila (2018, background): “The presynaptic terminals of different subsets of dopaminergic neurons (DANs), encoding positive or negative valence, occupy distinct, nonoverlapping compartments of the mushroom body neuropil which are precisely matched by the dendritic fields of discrete MBONs (Figure 1) [16,18,19,22,23,34 ,35,36]”
Defining and assessing animal pain (2014, unknown): “How nociceptive information is processed within the insect central nervous system remains almost entirely unknown (Johnson & Carder, 2012), although there is evidence that nociceptive information reaches higher learning centres in the insect brain (e.g. Waddell, 2013).”
Drosophila Learn Opposing Components of a Compound Food Stimulus (2014, background): “learning and others for aversive learning [3, 5–9].”
A Higher Brain Circuit for Immediate Integration of Conflicting Sensory Information in Drosophila. (2015, background): “Is the circuit element we identified indeed dedicated to immediate modulation, or could it be used to change CO2 avoidance more permanently? In other words, could the fly learn to stop avoiding CO2 after having experienced it in the context of food odor? During learning and memory, dopaminergic neur”
The complete connectome of a learning and memory centre in an insect brain (2017, background): “(4) There are postsynaptic densities, visible as black streaks hanging from the postsynaptic membrane.”
A connectome of a learning and memory center in the adult Drosophila brain (2017, background): “In addition to the circuit motifs anticipated from prior anatomical, behavioral and physiological stud- ies (Heisenberg, 2003; McGuire et al., 2005; Waddell, 2013; Hige et al., 2015a; Cohn et al., 2015; Owald et al., 2015), our comprehensive reconstruction shed light on some synaptic connec- tions…”
Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory (2015, background): “Dopamine is a major neuromodulator in the MB circuit (36, 71), and plays a dual role in learning and forgetting by signaling through two different dopamine receptors, dDA1 and DAMB, respectively (7).”
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila (2013, unknown): “…of the ab, a0b0, and g classes of MB neuron has been reported (Crittenden et al., 1998; Zars et al., 2000; Yu et al., 2006; Krashes et al., 2007; Wang et al., 2008; Akalal et al., 2010; Trannoy et al., 2011; Qin et al., 2012; Tanaka et al., 2008), until now a valence-restricted role has been…”
Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila (2015, background): “Value can be assigned to these odor representations during learning by the action of reinforcing dopaminergic neuronswhose presynaptic terminals are confined to discrete zones along the lobes of the MB (Schwaerzel et al., 2003; Riemensperger et al., 2005; Claridge-Chang et al., 2009; Aso et al., 201”