Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
By Chang Geol Lee, M. Heijn, E. Tomaso, G. Griffon-Etienne, M. Ancukiewicz, C. Koike, K. Park, N. Ferrara, Rakesh K. Jain, H. Suit and 1 more. Cancer Research, 2000
719 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/06b4ed6e269bee8bc382b8d3e0675c4da8377dd1
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Citations in the corpus
- Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. (2005, background): “Tumor growth, vascular density, oxygenation (pO2), apoptosis of tumor cells, IFP Decrease in tumor growth and IFP (73% in U87); increase in apoptosis; increase in pO2 in some tumors ( 51 )”
- High interstitial fluid pressure — an obstacle in cancer therapy (2004, background): “Treatment of immunocompromized mice bearing xenografts of human glioblastoma or adenocarcinoma tumours with a monoclonal antibody against VEGF was found to cause a greater than 70% reduction of tumour IF”
- Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors (2004, background): “We have recently shown that an anti-VEGF antibody can lower interstitial fluid pressure (IFP) in transplanted tumors in mice (3) and in rectal carcinomas in patients (4).”
- Angiogenesis in Cancer (2006, unknown): “…al 2002; Tong et al 2004; Winkler et al 2004); 4) permeability to large molecules is high (Yuan et al 1996; Tong et al 2004; Willett et al 2004; Winkler et al 2004); and 5) the pressure of microvascular and interstitial fluid is almost the same (Lee et al 2000; Tong et al 2004; Willet et al 2004).”
- Delivering nanomedicine to solid tumors (2010, background): “More importantly, from the transport point of view, tumor vessels appear less tortuous and better perfused after treatment, and the IFP is significantly reduced, which restores pressure gradients across the vessel wall and leads to a deeper penetration of molecules into tumors and to improved oxygen”