Pharmaceutical approaches to colon targeted drug delivery systems.

By M. K. Chourasia, S. Jain. Journal of Pharmacy & Pharmaceutical Sciences, 2003

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Microencapsulation of probiotics for gastrointestinal delivery. (2012, background): “The large intestine, unlike the rest of the GI tract, is home to a large concentration of indigenous bacterial species, which themselves offer an opportunity for targeted delivery as some polysaccharides (such as pectin [32]) are biodegraded by the colonic microflora.”
Gut microorganisms, mammalian metabolism and personalized health care (2005, background): “This metabolic repertoire predominantly comprises hydrolysis and reduction transformations, for example, decarboxylation, dealkylation, dehalogenation and deamination, in contrast to mammalian tissues, which have a greater propensity for oxidation and conjugatio”