Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations.

By L. Limbach, Yuchun Li, R. Grass, T. Brunner, M. Hintermann, M. Muller, Detlef Gunther, W. Stark. Environmental Science and Technology, 2005

778 citations recorded by the source corpus.

Subfields: Biomaterials, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/068e47d443af145568eaf33d0ce32202144d63cf

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In Materials Chemistry

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Citations in the corpus

• Assessing the risks of manufactured nanomaterials. (2006, background): “A recent investigation indicates that CeO2 nanoparticles are taken up into human fibroblasts in vitro ( 44 ).”
• Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, background): “Although the cause for high cellular uptake/interaction of TiO2 nanoparticles by cells has yet to be determined, it is possible that agglomerated TiO2 nanoparticles form particle clusters and thus accumulated higher amount of adsorbed protein compared with larger size particles, such as SiO2 nanopar”
• In vitro approaches to assess the hazard of nanomaterials (2017, background): “Thus, deposition of NMs concentration/dose onto the per cell surface is the dominant factor determining the rate of uptake and not particle number NM concentration per volume or total surface area of the material (Limbach et al., 2005; Teeguarden et al., 2007).”
• Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. (2007, background): “Examples of this type of agglomeration can be seen in electron micrographs of a number of metal oxides (Limbach et al., 2005), C60 fullerenes (Fortner et al., 2005), and carbon nanotubes (Lisunova et al., 2006).”
• Not ready to use – overcoming pitfalls when dispersing nanoparticles in physiological media (2008, background): “Many individual aspects of NP dispersion and protein adsorption have been investigated recently (Limbach et al. 2005; Hyung et al. 2007; Nepal & Geckeler 2007; Patil et al. 2007; Richter et al. 2007; Wick et al. 2007), including the binding enthalpy of proteins on polymer particles (Cedervall et…”
• Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety (2007, background): “Cerium oxide NP uptake into fibroblast cell cultures is strongly inversely dependent on particle size, and uptake is faster than would be predicted by diffusion, suggesting a biological uptake process at the cell surface (Limbach et al., 2005).”