Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila.
By Tomoatsu Ikeya, M. Galic, Priyanka Belawat, K. Nairz, E. Hafen. Current Biology, 2002
753 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0610f791ea89f4dd5b5400413238b953e5de8dcf
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In Cellular and Molecular Neuroscience
In Molecular Biology
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Citations in the corpus
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “, 1999); UAS-reaper (UAS-rpr) and dilp2-GAL4 (Ikeya et al., 2002) were kind gifts from Ernst Hafen.”
- Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development (2013, background): “S3A) and transcripts for the major DILPs (DILP2 and DILP5) that are known to regulate larval growth in response to nutrients (28) were not altered (Fig.”
- Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. (2003, background): “2002) and that food limitation decreases the Drosophila insulin-like peptide (DILP) levels (Ikeya et al. 2002; Rulifson et al. 2002).”
- Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides (2010, background): “All seven DILPs possess the ability to promote growth, with DILP2 the most potent, and these ligands therefore probably all act as DInR agonists [9].”
- 1.3 – Vitellogenesis and Post-Vitellogenic Maturation of the Insect Ovarian Follicle (2005, background): “Furthermore, the expression of DILP5 in follicular cells of vitellogenic follicles (Ikeya et al., 2002) also suggests the existence of a parallel autocrine/paracrine pathway that regulates follicle growth and maturation.”
- Dietary protein mediates a trade-off between larval survival and the development of male secondary sexual traits (2013, background): “…animal taxa, this metabolic signalling pathway regulates the rate of somatic tissue growth by linking the availability of dietary nutrients to cell growth and proliferation (Britton & Edgar 1998; Brogiolo et al. 2001; Britton et al. 2002; Ikeya et al. 2002; Teleman 2009; Tennessen & Thummel 2011).”