SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

By V. Vitart, I. Rudan, C. Hayward, N. Gray, J. Floyd, C. Palmer, S. Knott, I. Kolčić, O. Polašek, J. Graessler and 30 more. Nature Genetics, 2008

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Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study (2008, background): “Biologic Mechanisms SNPs in SLC2A9 recently have been identified as associated with UA levels (12–15), and were associated with low renal fractional excretion of UA (15), the most common cause for hyperuricemia (37).”
Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations (2009, result): “In accordance with previous genome-wide studies, the strongest effect on serum UA concentrations was detected for SLC2A9, [6–9] coding for GLUT9, which has been shown to be strongly associated with hyperuricemia and gout and to serve as a highcapacity urate transporter in humans [8,10].”
Glucose transporters in the 21st Century. (2010, background): “Several groups reported genome-wide association studies (GWAS) that identified single-nucleotide polymorphisms in the Glut9 gene that were linked with elevated plasma uric acid levels (26, 42).”