A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

By H. Plovier, A. Everard, Céline Druart, C. Depommier, M. Van Hul, L. Geurts, J. Chilloux, N. Ottman, T. Duparc, Laeticia Lichtenstein and 15 more. Nature Medicine, 2016

1,900 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0598fedc57a2da1dd2c78077369b29cc97eee289

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Patrice D Cani
2. W. D. de Vos
3. C. Belzer
4. Faming Zhang
5. Ting Zhang
6. Lei Cheng
7. H. Buch
8. Qianqian Li

In Physiology

1. W. D. de Vos
2. S. Ghosh
3. D. van Sinderen
4. Patrice D Cani
5. D. Jump
6. T. Postler

Citations in the corpus

• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “muciniphila supplementation have been attributed in part to a bacterial outer membrane protein that interacts with Tolllike receptor 2 and restores gut barrier function (Plovier et al., 2017).”
• Akkermansia muciniphila is a promising probiotic (2019, background): “muciniphila grown on synthetic media was confirmed to be safe for human administration (Plovier et al., 2017).”
• Human gut microbiome: hopes, threats and promises (2018, background): “105 Recently identified on the outer membrane of this bacteria, this protein has been shown to play immunomodulatory roles both in vivo and in vitro, 105 109 and this effect of A. muciniphila on the immune system is important because A. muciniphila has recently been shown to delay the onset of type…”
• Role of gut microbiota in type 2 diabetes pathophysiology (2020, background): “Amuc_1100 also inhibits cannabinoid receptor type 1 (CB1) in the gut, which in turn, reduces gut permeability and systemic LPS levels [37].”
• The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “Recently, a mechanistic explanation involving TLR signaling via a specific pilus-associated protein has been provided (448, 449).”