Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
By A. Weng, A. Ferrando, W. Lee, John P. Morris, L. Silverman, Cheryll Sanchez-Irizarry, S. Blacklow, A. Look, J. Aster. Science, 2004
2,872 citations recorded by the source corpus.
Subfields: Hematology, Molecular Biology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/05642b715dc8a2e5b0419796e2a73cf399feabdf
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In Hematology
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- Nikolaus Schultz
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- Li Zheng
- Leonard I. Zon
Citations in the corpus
- PI5P4Kγ functions in DTX1-mediated Notch signaling (2018, background): “By contrast, gain-of-function mutations lead to diseases like T-cell acute lymphoblastic leukemia and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (9, 10).”
- Notch signaling mediates hypoxia-induced tumor cell migration and invasion (2008, background): “Finally, deregulated Notch signaling correlates with cancer, for example in T cell lymphoblastic leukemia, where the majority of patients carry mutations in NOTCH 1 (21), and in breast cancer, where elevated expression of the activated form of Notch is observed (22, 23).”
- Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. (2008, background): “Mutations in the NOTCH1 heterodimerization domain were identified in P5 and P10 blast cells, consistent with the frequent gain-of-function NOTCH1 mutations in T-ALL (29).”
- Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “Inhibitors of this complex slow the growth of Notch-dependent tumors such as medulloblastoma and T-cell leukemia (8, 9, 38).”
- Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. (2006, background): “Activation of NOTCH1 signaling has been recently linked to several malignancies, including glioma (Fan et al., 2004; Purow et al., 2005; Radtke and Clevers, 2005; Weng et al., 2004).”