Why degradable polymers undergo surface erosion or bulk erosion.

By F. von Burkersroda, Luise Schedl, A. Göpferich. Biomaterials, 2002

1,010 citations recorded by the source corpus.

Subfields: Polymers and Plastics, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/05016457e64611b95087da7a5c253d629c941247

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Polymers and Plastics

1. A. Le Duigou
2. P. Davies
3. P. Halley
4. C. Baley
5. Alain Bourmaud
6. L. Avérous

In Surfaces, Coatings and Films

1. C. Wischke
2. S. Schwendeman

Citations in the corpus

• Polymer biodegradation: mechanisms and estimation techniques. (2008, background): “The biodeterioration of thermoplastic polymers could proceed by two different mechanisms, i.e., bulk and surface erosion (von Burkersroda et al., 2002; Pepic et al., 2008).”
• Accelerated ageing of polylactide in aqueous environments: Comparative study between distilled water and seawater (2014, result): “It appears here that during hydrolytic degradation the PLA undergoes bulk degradation, as previously noted [36,37].”
• The Chemical Recycling of PLA: A Review (2020, background): “In aqueous systems, in which PLA has poor solubility, the hydrolysis can be achieved by bulk or surface erosion (Scheme 2) [66].”
• Lifetime prediction of biodegradable polymers (2017, methodology): “It has been shown that since the rate of water uptake is much faster than that of hydrolysis in bulk eroding polymers, such as PLA, then the kinetics of degradation are under chemical control [49, 107, 109] and the mechanisms of polyester hydrolysis in different media are relatively well understood ”
• Bone tissue engineering: A review in bone biomimetics and drug delivery strategies (2009, background): “Biodegradation of polymers can be generally categorized as bulk or surface degradation.(230,231) In bulk degradation, the rate of water penetration exceeds the degradation and solubilization rate of surface molecules resulting in a bulk material degradation and consequently the loss of macroscopic m”
• Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. (2008, background): “As PLGA matrices are subjected to bulk erosion at acidic and neural pH values (von Burkersroda et al., 2002) it can take some time ntil the polymer is degraded down to a critical chain length and lag phase will appear in the release profile for erosion-controlled ormulations.”
• Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. (2006, background): “Schematic illustration of surface- and bulk-erosion processes in the polymer matrix (reprinted from [45] with permission from Elsevier).”