Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.

By Kevin J. Kauffman, J. R. Dorkin, Jung H. Yang, M. Heartlein, F. Derosa, Faryal F. Mir, Owen S. Fenton, Daniel G. Anderson. Nano letters (Print), 2015

688 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/04e23aab5496491e6766dd5bae825c5fda72a6e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. J. Kulkarni
2. Camilla Hald Albertsen
3. K. Petersson
4. Marianne Lind
5. J. Simonsen
6. D. Witzigmann

In Molecular Biology

1. J. Kulkarni
2. Camilla Hald Albertsen
3. K. Petersson
4. Marianne Lind
5. J. Simonsen
6. D. Witzigmann

Citations in the corpus

• Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. (2019, neutral): “10,13 In this review, we discuss the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in biomaterials and delivery strategies, and we present an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination.”
• The role of lipid components in lipid nanoparticles for vaccines and gene therapy (2022, positive): “As discussed above, PEG desorption rate can be controlled by formulating LNPs using PEG-lipids with different acyl chain lengths [24,49,51].”