The origins and evolution of "controlled" drug delivery systems.

By Allan S. Hoffman. Journal of Controlled Release, 2008

682 citations recorded by the source corpus.

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On the nature of biomaterials. (2009, background): “We also recognise that some materials are used with the express intention of delivering some biologically or pharmacologically active agent to the patient; the concept of drug delivery devices is of course well known [23].”
Advanced Materials and Processing for Drug Delivery: The Past and the Future (2012, background): “Block copolymers have captivated the imagination of researchers since the early days of drug delivery because of their remarkable chemical flexibility [35].”
Targeted drug delivery to tumors: Myths, reality and possibility (2011, positive): “During the last several decades controlled drug delivery technology has advanced significantly, leading to the development of various clinical formulations improving patient compliance and convenience [1].”
Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. (2012, background): “A wide range of delivery materials have been fabricated using polyesters based on lactide, glycolide, caprolactone, and dioxanone, polyanhydrides based on sebacic and adipic acid, as well as polyamides, polycarbonates, polyorthoesters, and phosphate-based polymers, which have been reviewed in detail”