Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells

By J. Rehman, D. Traktuev, Jingling Li, Stephanie Merfeld‐Clauss, C. Temm-Grove, Jason E. Bovenkerk, Carrie L. Pell, B. Johnstone, R. Considine, K. March. Circulation, 2004

2,281 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/046a7ff4881898e2fd8b2a9c73972873bb66d155

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In Genetics

1. A. Caplan
2. L. Meirelles

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1. K. Weiss
2. A. Caplan
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4. C. Westenfelder
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Citations in the corpus

• Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. (2007, background): “Furthermore, human adipose stromal cells, cell type that is very similar to MSC, secrete angiogenic and antiapoptotic factors that elicit cardiovascular protection (31).”
• Clinical Treatment of Radiotherapy Tissue Damage by Lipoaspirate Transplant: A Healing Process Mediated by Adipose-Derived Adult Stem Cells (2007, methodology): “6 through 8).”
• Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy (2016, background): “In addition, ADSCs have other beneficial characteristics such as their lack of both HLAclass II antigen expression and thus xenogeneic transplantation possibility (85); their ability to migrate through α4ß1 expression (86); and high antioxidant, anti-apoptotic, immunomodulatory, and anti-inflammator”
• Cell-Assisted Lipotransfer: Supportive Use of Human Adipose-Derived Cells for Soft Tissue Augmentation with Lipoinjection (2006, positive): “dition.(31) This effect may also contribute to the decreased volume of central necrosis and more prominent microvasculature in the outer layers of the CAL fat seen in this study.”
• Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates (2006, background): “This characteristic may contribute to potentialities of ASCs other than mesenchymal progenitors, such as endothelial (Miranville et al., 2004; Rehman et al., 2004; Planat-Benard et al., 2004b) or pericyte progenitors.”
• Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells (2007, background): “Third, ASCs are known to release angiogenic growth factors in response to hypoxia and other conditions [13], and these factors influence surrounding host tissue.”
• Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. (2007, background): “The concentrations of several cytokines and ECM proteins were measured using sandwich ELISA kits (vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor (TGF)-b1 and b2, hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), platelet-d”
• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “Also, adipose tissue-derived MSCs have been shown to express HGF, VEGF, transforming growth factor beta (TGF-b), basic fibroblast growth factor (bFGF, aka FGF2) and granulocyte–macrophage colony-stimulating factor (GM-CSF), and the expression of these molecules was found to increase under hypoxic cu”