Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

By M. van der Sluis, B. D. de Koning, A. D. de Bruijn, A. Velcich, J. Meijerink, J. V. van Goudoever, H. Büller, J. Dekker, I. van Seuningen, I. Renes and 1 more. Gastroenterology, 2006

1,641 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0407515e7ed62f866f091a0a06f64f43f863bdf6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. D. Kufe
2. L. Hooper
3. G. Núñez
4. J. Turner

In Molecular Biology

1. M. Johansson
2. G. Hansson
3. G. Núñez
4. M. Zeng
5. N. Inohara
6. A. Macpherson
7. Severine Vermeire
8. M. Vancamelbeke

In Oncology

1. G. Núñez
2. Severine Vermeire
3. D. Kufe
4. N. Inohara
5. M. Vancamelbeke
6. M. Zeng

Citations in the corpus

• Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates (2014, neutral): “The long-term effects of low dietary MACs on the gut mucus depletion, barrier function, and inflammation have not been studied in detail; however, genetic mucus depletion in mice results in microbiota-induced inflammation and ultimately colitis (Johansson et al., 2014; Van der Sluis et al., 2006).”
• A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility (2016, neutral): “Genetic ablation of Muc2 in mice brings bacteria into close contact with the epithelium, leading to inflammation and colon cancer (Van der Sluis et al., 2006).”
• The intestinal barrier: a fundamental role in health and disease (2017, background): “critical in protection against disease, as Muc2 knock-out mice spontaneously develop colitis [9].”
• Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review. (2019, background): “Indeed, the SUML was shown to be integral to gut health as mice deficient in mucin 2 (MUC2), a glycoprotein which forms the bulk of the mucus, spontaneously developed colitis, with a presentation similar to dextran sulfate-sodium–induced colitis (124).”
• Mechanisms of inflammation-driven bacterial dysbiosis in the gut (2016, positive): “Lack of MUC2 mucin in mice is associated with increased bacterial adhesion to the surface epithelium, increased intestinal permeability and enhanced susceptibility to colitis induced by DSS.(74,75) N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetylneuraminic acid (sialic acid), L-fucose and ”